/* Circulatory Science Review - v22 */
@import url('https://fonts.googleapis.com/css2?family=Lato:wght@400;700&family=Playfair+Display:wght@600;700&display=swap');

*,*::before,*::after{box-sizing:border-box;margin:0;padding:0}

:root{
  --csr-navy:#1a2744;
  --csr-teal:#2a7f8f;
  --csr-coral:#e07c5a;
  --csr-lightgray:#f4f6f8;
  --csr-white:#fff;
  --csr-text:#333;
  --csr-muted:#6c757d;
  --csr-serif:'Playfair Display',Georgia,serif;
  --csr-sans:'Lato','Helvetica Neue',Arial,sans-serif;
}

html{font-size:16px;scroll-behavior:smooth}
body{
  font-family:var(--csr-sans);
  color:var(--csr-text);
  background:var(--csr-lightgray);
  line-height:1.7;
  -webkit-font-smoothing:antialiased;
}

/* ---------- LAYOUT ---------- */
.csr-wrap{max-width:760px;margin:0 auto;padding:0 16px}

/* ---------- SPONSORED BAR ---------- */
.csr-sponsored{
  background:var(--csr-navy);
  color:rgba(255,255,255,.85);
  text-align:center;
  font-size:.75rem;
  letter-spacing:.06em;
  padding:6px 16px;
  text-transform:uppercase;
}

/* ---------- HEADER ---------- */
.csr-header{
  background:var(--csr-white);
  border-bottom:3px solid var(--csr-navy);
  padding:18px 0 14px;
}
.csr-header__inner{display:flex;justify-content:space-between;align-items:baseline;flex-wrap:wrap;gap:4px}
.csr-header__brand{
  font-family:var(--csr-serif);
  font-weight:700;
  font-size:1.35rem;
  color:var(--csr-navy);
}
.csr-header__cat{
  font-size:.72rem;
  text-transform:uppercase;
  letter-spacing:.08em;
  color:var(--csr-muted);
}

/* ---------- HERO ---------- */
.csr-hero{background:var(--csr-white);padding:38px 0 32px;text-align:center}
.csr-hero__title{
  font-family:var(--csr-serif);
  font-size:1.75rem;
  font-weight:700;
  color:var(--csr-navy);
  line-height:1.3;
  margin-bottom:22px;
}
.csr-hero__stats{
  display:flex;
  justify-content:center;
  gap:28px;
  flex-wrap:wrap;
}
.csr-hero__stat{text-align:center}
.csr-hero__stat-num{
  display:block;
  font-family:var(--csr-serif);
  font-size:1.9rem;
  font-weight:700;
  color:var(--csr-teal);
}
.csr-hero__stat-label{font-size:.8rem;color:var(--csr-muted)}

/* ---------- SECTION FOUNDATIONS ---------- */
.csr-section{padding:36px 0}
.csr-section--alt{background:var(--csr-lightgray)}
.csr-section--white{background:var(--csr-white)}
.csr-section__heading{
  font-family:var(--csr-serif);
  font-size:1.35rem;
  font-weight:700;
  color:var(--csr-teal);
  margin-bottom:18px;
  border-left:4px solid var(--csr-coral);
  padding-left:14px;
}
.csr-section p{margin-bottom:14px}
.csr-section p:last-child{margin-bottom:0}

/* ---------- CARDS ---------- */
.csr-card{
  background:var(--csr-white);
  border:2px solid var(--csr-navy);
  border-radius:4px;
  padding:22px 20px;
  margin-bottom:18px;
}
.csr-card__title{
  font-family:var(--csr-serif);
  font-size:1.05rem;
  font-weight:600;
  color:var(--csr-navy);
  margin-bottom:8px;
}
.csr-card__ref{
  font-size:.75rem;
  color:var(--csr-coral);
  font-weight:700;
  margin-bottom:6px;
}
.csr-card p{font-size:.93rem}

/* ---------- COMPOUND GRID ---------- */
.csr-compounds{
  display:grid;
  grid-template-columns:1fr 1fr;
  gap:16px;
}
.csr-compound{
  background:var(--csr-white);
  border:2px solid var(--csr-navy);
  border-radius:4px;
  padding:18px 16px;
}
.csr-compound__name{
  font-family:var(--csr-serif);
  font-weight:600;
  font-size:1rem;
  color:var(--csr-navy);
  margin-bottom:4px;
}
.csr-compound__ref{
  font-size:.72rem;
  color:var(--csr-coral);
  font-weight:700;
  margin-bottom:6px;
}
.csr-compound p{font-size:.88rem}

/* ---------- AWARENESS LIST ---------- */
.csr-awareness-list{list-style:none;padding:0}
.csr-awareness-list li{
  position:relative;
  padding:8px 0 8px 22px;
  font-size:.93rem;
  border-bottom:1px solid #e4e8ec;
}
.csr-awareness-list li:last-child{border-bottom:none}
.csr-awareness-list li::before{
  content:'';
  position:absolute;
  left:0;top:16px;
  width:8px;height:8px;
  background:var(--csr-coral);
  border-radius:50%;
}
.csr-awareness-list .csr-ref-tag{
  font-size:.72rem;
  color:var(--csr-coral);
  font-weight:700;
}

/* ---------- PRODUCT OFFER ---------- */
.csr-offer{text-align:center;padding:40px 0}
.csr-offer__heading{
  font-family:var(--csr-serif);
  font-size:1.4rem;
  font-weight:700;
  color:var(--csr-navy);
  margin-bottom:6px;
}
.csr-offer__sub{font-size:.9rem;color:var(--csr-muted);margin-bottom:28px}
.csr-offer__grid{
  display:grid;
  grid-template-columns:1fr 1fr 1fr;
  gap:16px;
  margin-bottom:24px;
}
.csr-offer__pkg{
  background:var(--csr-white);
  border:2px solid var(--csr-navy);
  border-radius:4px;
  padding:20px 12px 18px;
  display:flex;flex-direction:column;align-items:center;
  transition:box-shadow .2s;
}
.csr-offer__pkg:hover{box-shadow:0 4px 16px rgba(26,39,68,.12)}
.csr-offer__pkg--featured{border-color:var(--csr-coral);border-width:3px}
.csr-offer__pkg img{max-width:100%;height:auto;margin-bottom:12px}
.csr-offer__pkg-label{
  font-family:var(--csr-serif);
  font-weight:700;
  font-size:1.05rem;
  color:var(--csr-navy);
  margin-bottom:10px;
}
.csr-offer__cta{
  display:inline-block;
  background:var(--csr-coral);
  color:var(--csr-white);
  font-weight:700;
  font-size:.88rem;
  padding:10px 22px;
  border-radius:4px;
  text-decoration:none;
  text-transform:uppercase;
  letter-spacing:.04em;
  transition:background .2s;
}
.csr-offer__cta:hover{background:#c9654a}
.csr-offer__guarantee{
  font-size:.85rem;
  color:var(--csr-muted);
  margin-top:6px;
}

/* ---------- FAQ ---------- */
.csr-faq details{
  border:2px solid var(--csr-navy);
  border-radius:4px;
  margin-bottom:12px;
  background:var(--csr-white);
}
.csr-faq summary{
  padding:14px 18px;
  cursor:pointer;
  font-weight:700;
  font-size:.95rem;
  color:var(--csr-navy);
  list-style:none;
}
.csr-faq summary::-webkit-details-marker{display:none}
.csr-faq summary::before{
  content:'+';
  display:inline-block;
  width:20px;
  font-size:1.1rem;
  color:var(--csr-coral);
  font-weight:700;
}
.csr-faq details[open] summary::before{content:'\2212'}
.csr-faq details div{
  padding:0 18px 16px;
  font-size:.9rem;
  line-height:1.65;
}

/* ---------- REFERENCES ---------- */
.csr-references{
  background:var(--csr-white);
  border:2px solid var(--csr-navy);
  border-radius:4px;
  padding:22px 20px;
}
.csr-references__title{
  font-family:var(--csr-serif);
  font-size:1.1rem;
  font-weight:700;
  color:var(--csr-navy);
  margin-bottom:12px;
}
.csr-references ol{
  padding-left:22px;
  font-size:.78rem;
  color:var(--csr-muted);
  line-height:1.6;
}
.csr-references ol li{margin-bottom:4px}

/* ---------- DISCLAIMERS ---------- */
.csr-disclaimers{
  background:var(--csr-lightgray);
  border-top:2px solid var(--csr-navy);
  padding:30px 0;
}
.csr-disclaimers__title{
  font-family:var(--csr-serif);
  font-size:1.1rem;
  font-weight:700;
  color:var(--csr-navy);
  margin-bottom:14px;
}
.csr-disc-block{margin-bottom:16px}
.csr-disc-block:last-child{margin-bottom:0}
.csr-disc-block h4{
  font-size:.82rem;
  text-transform:uppercase;
  letter-spacing:.06em;
  color:var(--csr-coral);
  margin-bottom:4px;
}
.csr-disc-block p{font-size:.8rem;color:var(--csr-muted);line-height:1.55}

/* ---------- FOOTER ---------- */
.csr-footer{
  background:var(--csr-navy);
  color:rgba(255,255,255,.7);
  padding:24px 0;
  text-align:center;
  font-size:.78rem;
}
.csr-footer__links{
  display:flex;
  justify-content:center;
  gap:20px;
  flex-wrap:wrap;
  margin-bottom:10px;
}
.csr-footer__links a{
  color:rgba(255,255,255,.8);
  text-decoration:none;
  transition:color .2s;
}
.csr-footer__links a:hover{color:var(--csr-coral)}

/* ---------- MOBILE ---------- */
@media(max-width:640px){
  .csr-hero__title{font-size:1.35rem}
  .csr-hero__stats{gap:16px}
  .csr-hero__stat-num{font-size:1.5rem}
  .csr-compounds{grid-template-columns:1fr}
  .csr-offer__grid{grid-template-columns:1fr}
  .csr-section__heading{font-size:1.15rem}
  .csr-header__brand{font-size:1.15rem}
  .csr-card{padding:16px 14px}
}